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Published Research (Scientific Record) Foundational Mechanism 2003 Original PT-141 mechanism / clinical entry paper Molinoff, Shadiack, Earle, Diamond, and Quon described PT-141 as a synthetic peptide analogue of -MSH that is an agonist at MC3R and MC4R, expressed primarily in the central nervous system
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A 10-week MeDi intervention in World Trade Center responders with PTSD significantly reduced inflammatory markers such as CRP and lessened PTSD symptom severity compared to standard nutritional advice (Arcan et al., 2024)
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