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Based on these observations, large-scale, prospective, multicenter registry studies are warranted to confirm generalizability, particularly in primary care settings, and to provide sufficient power for robust multivariable modeling that can validate the exploratory factors associated with response

Similar to Ipamorelin, GHRP-2, and GHRP-6 lead to an increase in appetite and weight gain Furthermore, GHRP-2 and GHRP-6 are not as selective as Ipamorelin

The difference with compounded GLP-1s is that patients are doing the math themselves instead of relying on pre-filled pens with fixed doses

This adaptation pattern is why the slow titration schedule exists, and why rushing through dose increases almost always backfires