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03 Investment strategy Tirzepatide was approved for marketing in May 2022

EBITDA margin guidance of 30-32% going forward is conservative relative to the 33.6% delivered in FY26 management is building in a buffer for geopolitical uncertainty and the loss of PLI benefits

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5-Amino-1MQ oral and subcutaneous route comparison Factor Administration Oral capsules Capsule taken by mouth Subcutaneous injection Reconstituted solution placed under the skin Factor Commonly discussed research amounts Oral capsules 50 to 150 mg per day in community reports Subcutaneous injection 2.5 to 5 mg per day in community reports Factor Frequency Oral capsules Once daily or split between morning and midday Subcutaneous injection Usually discussed as once daily, with some split examples Factor Absorption evidence Oral capsules 38.4% oral bioavailability in one rat study