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The first study to demonstrate superiority over placebo was the LEADER study, in which 9,340 patients were assigned to either liraglutide or placebo

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Lean mass preservation, fat mass reduction and bone strength will sit alongside weight reduction in trial design

While there is no clinical diagnosis for this exactly, it is a side effect sometimes noted by those who are using semaglutide (Ozempic or Wegovy) injections to lose weight