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Presented for research literature review only Rababa'h SY et al
Effects of diet and antihyperglycemic drugs on erectile dysfunction: A systematic review 3
The molecule that emerged from this foundational work carried a disabling flaw as a therapeutic scaffold: native GLP-1 is degraded almost immediately by the serine protease dipeptidyl peptidase-4 (DPP-4), which cleaves the peptide between residues 8 and 9 and confers a circulating half-life of under two minutes [4]
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