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Refrigeration isn't strictly necessary, but it certainly doesn't hurt

10.1111/j.1067-1927.2004.12402.x 21 MaquartF

PubMed PMID: 820366

Hormonal Imbalances Growth hormone-related peptides , such as GHK-Cu or CJC-1295 , can disrupt the bodys endocrine system if used excessively or without medical oversight, leading to side effects ranging from fatigue and mood changes to more severe imbalances