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This may be attained by harnessing compounds that deter the antioxidant system by inhibiting these signaling pathways which play roles in upregulating the antioxidants in cancer

Both selective AMYR agonists, and dual CTR and AMYR agonists such as sCT 5,6,7 , have demonstrated efficacy in controlling appetite and body weight, however this is not seen with a CTR-selective agonist 9

Generally, the eligibility criteria include having a body mass index (BMI) that categorizes the individual as overweight or obese, typically a BMI of 30 or higher, or a BMI of 27 or higher if accompanied by weight-related health conditions such as type 2 diabetes, hypertension, or dyslipidemia