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GLP-1RAs mitigate these adverse impacts by enhancing fatty acid oxidation via the Creb5/NR4a1 signaling axis, thereby reducing mitochondrial damage, lipid accumulation, and ATP deficiency (77, 78, 83)
In order to ascertain the relative levels of GLP-1R mRNA and protein expression in vivo , the following tissues were harvested from mGlp-1r , hGLP-1R , and Glp-1r / mice: heart, islets, lung, kidney, stomach, small intestine, and liver ( Figure 8A )
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