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Those papers which formed the preclinical rationale for dihexa's nootropic claims and for Athira's NIH grant applications had been cited as evidence that dihexa promoted synaptogenesis at rates far exceeding BDNF
For example, evodiamine has been found to inhibit histone lactylation at the HIF-1 promoter, suppressing angiogenesis and programmed death-ligand 1 expression while inducing ferroptosis in prostate cancer cells (122)
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