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Glutathione (GSH) is highly abundant in all cell compartments and is the major soluble antioxidant
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The results showed that VRK2 knockdown could induce an increase of ROS and decline of cell viability and GSH following TBHP treatment, while these alterations could be partly reversed by ectopic SLC7A11 expression but not GCLC or GSS expression (Fig
This mechanism is consistent with prior findings where Spirulina -derived metabolites promoted Nrf2 activation and reduced oxidative stress in hepatic injury models (Sibiya et al., 2022)
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