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Application of omics studies in durians Omics studies have five main applications in durians: (1) evolutionary studies, (2) understanding the durian fruit ripening mechanism, (3) identifying genetic markers for breeding, (4) discovery of bioactive compounds for pharmaceutical and industrial applications, and (5) applications in the post-harvest processing

Given that tumor heterogeneity profoundly affects drug response, PDO biobanks are now being designed to include multiple patient-derived samples, capturing regional heterogeneity and subclonal architecture

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Importantly, 5FU-based combination treatment also shows an increase in mitochondrial mass (FOLFOX (5FU + 1 M oxaliplatin) or FOLFIRI (5FU + 5 nM SN38, active metabolite of irinotecan)) that we attribute to 5FU-imposed stress, given that single-agent oxaliplatin or SN38 do not promote the same degree of mitochondrial adaptation (Extended Data Fig