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Cellular senescence is characterized by a stable arrest in the cell cycle and encompasses a range of cellular changes that culminate in the development of a complex, pro-inflammatory secretory profile known as the senescence-associated secretory phenotype (SASP), which plays a critical role in fibrosis and tumors by affecting numerous processes, including invasion and therapy resistance 10

10.4103/2045-9912.229599 Med Gas Res

Son et al, 2013)

In contrast to -glutamylcysteine synthetase, glutathione synthetase accepts a large variety of glutamyl-modified analogs of -glutamylcysteine, but is much more specific for cysteine-modified analogs of -glutamylcysteine