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in the Journal of Pharmacology and Experimental Therapeutics (which established Dihexas HGF/c-Met mechanism via Morris water maze rescue with HGF antagonist blockade) was the subject of an Expression of Concern in 2021 and was formally retracted in April 2025 by the publishing journal following investigation into image manipulation

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Research studies have used 30-day minimum treatment courses, 12-week protocols for skin rejuvenation, and 6-month protocols for hair growth applications

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Sterility is another issue since many take BPC-157 by injection, any contamination in the preparation could cause infections or other reactions

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