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(2014, Nature Medicine) established NNMT as a major regulator of metabolic rate in white adipose tissue, showing that NNMT knockdown in mice produced a lean phenotype with elevated energy expenditure providing the foundational rationale for NNMT inhibition as a metabolic research target
Once evidence pointed to their weight-loss benefits, the agency began to approve some though not all of these medications for the treatment of obesity, too
Bonus: this can help constipation also!" she says
Daily use is best treated as a vet-guided decision, especially if your dog has medical conditions or takes medications
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