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FDA nonclinical toxicology review (2023-2024) flagged DNA damage in pituitary cells and injection-site necrosis in animal studies, plus immunogenicity and impurity risks from compounded material, alongside GH/IGF-1-axis effects such as fluid retention, joint discomfort, flushing, and headache reported by users
This genetic condition affects the optic nerve, and cyanocobalamin can accelerate optic atrophy in affected individuals
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The placebo group lost 3.1%
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