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Studies suggest that most people discontinue their use due to the high cost and adverse gastrointestinal side-effects
Protection of bone marrow transplant recipients from lethal doses of methotrexate by the generation of methotrexate-resistant bone marrow
OptumRx (owned by UnitedHealthcare), CVS Caremark (CVS Health which also owns Aetna), and Express Scripts (Cigna) decide which pharmacies patients must use, which medicines they can take, how much patients will pay at the pharmacy counter, and how much pharmacies will be reimbursed for filling prescriptions
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