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The problem surfaced in clinical trials run in 1992 by Mojsov and David Nathan, a physician and expert in type 2 diabetes at MGH, and those of Holst and Nauck (Molteni, Chen)

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By controlling for BMI, diabetes, and other health factors, the study strengthens the link between GLP-1 exposure and enhanced sperm count, suggesting a potential therapeutic role for GLP-1s in male infertility management