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In aged rats with induced cognitive deficits, Dihexa restored memory performance to levels comparable to healthy young animals through structural increases in dendritic spine density

Researchers attribute these effects to its regulation of nitric oxide pathways and cytoprotective influence on the gut lining

599 The interlaminar astrocytes (which populate brains of high primates and are not present in other species 32,33 ) are highly vulnerable to AD pathology: at the advanced stages of the disease interlaminar astrocytes disappear, 600 although how this impacts on the disease pathophysiology remains unknown