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Brown LF, et al
These comparative studies establish the pharmacological basis for the different biological profiles of MT-1 versus MT-II , with MT-1s MC1R preference explaining its predominantly pigmentary and skin photoprotection biology in contrast to MT-IIs broader melanocortin receptor activation producing pro-sexual, pro-erectile, and central appetite effects alongside pigmentation
Lower variability in drug exposure facilitates more predictable dose-response relationships and simplifies dose selection in clinical practice
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