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256 Collectively, the Notch pathway undergoes dynamic rewiring in response to therapeutic pressure, reinforcing its role in resistance biology and validating its potential as a target for rational combinatorial interventions
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Reduction of other inflammatory biomarkers has also been reported following GLP-1RA treatment in rodent models of cerebral ischemia, namely myeloperoxidase, IL-1, IL-6, IL-18, and cyclooxygenase-2 (COX-2), the latter through increasing expression of islet-brain-1 (IB1) [72,73,74]
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