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The primary mechanism involves direct upregulation of vascular endothelial growth factor (VEGF) and VEGFR2 receptor expression a process documented across more than 40 individual published studies

Measurable weight loss typically defined as a reduction of 5% or more in body weight may become apparent between weeks four and twelve , depending on the dose reached and individual factors

Autoimmune hepatitis The autoantibodies usually seen in autoimmune hepatitis are antinuclear antibody, antismooth muscle antibody, and anti-liver-kidney microsomal antibody, and patients need to be tested for them

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