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The aim of the present narrative review is to provide an integrative synthesis centered on melatonin, examining how its age-related decline mechanistically connects circadian disruption, sleep impairment, chrononutritional factors, and antioxidant defenses
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However the effect of IGF1 in differentiated muscle is limited by IRS1 ubiquitination and proteasome-mediated breakdown
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![Oral Small-Molecule GLP-1 Receptor Agonists: Mechanistic Insights and Emerging Therapeutic Strategies[v1]](https://www.preprints.org/frontend/manuscript/7be468775bea75bf2036c55c34b8f0dc/download_pub/figure/graphic_abstract.jpg)
