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Mel has been shown to regulate multiple molecular pathways, including inflammation, oxidative stress, apoptosis, and autophagy, under various pathophysiological conditions.32 Cas-3 is the most critical executioner in the caspase family and represents the final common substrate of both intrinsic and extrinsic apoptotic pathways.32 Once activated, Cas-3 cleaves this substrate, thereby reflecting the progression of apoptosis.33 In the present study, CARB treatment appeared to initiate this process in ovarian tissue, as evidenced by intense Cas-3 immunoreactivity
2015;10(12):e0143005
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244 Conclusions and future perspectives Once inside a cell, cysteine can have different fates, including the synthesis of glutathione or proteins, oxidative or non-oxidative catabolism, and reversible post-translational protein modification, each of which can contribute to the development and progression of cancer (Fig
