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Furthermore, MD revealed decreased flexibility of p53 TAD2 in complex with FOXO4-DRI compared to the FOXO4 FH -bound state with RMSDs of 1 heteronuclear NOE data was recorded using the HSQCNOEF3GPSI bruker pulse sequence (32 scans, 256 points in F1, 1024 points in F2, 1278.772 Hz spectral width in F1, 9615.385 Hz spectral width in F2) using a three seconds saturation period

TB-500, in contrast, is a stable, synthetic fragment that retains the key activity-driving region of TB-4

Always use new sterile syringes for each injection to prevent contamination and ensure accurate dosing

The absence of safety data in these populations should inform clinical decision-making and prescribing practices