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Understanding the Risks of Misuse and Off-Label Prescribing The growing trend of individuals who are not medically eligible seeking and sometimes obtaining GLP-1 medications like Ozempic for purely cosmetic weight loss highlights a serious concern regarding misuse and inappropriate off-label prescribing
Bowers and colleagues demonstrated in normal men that a GH-releasing peptide given with GHRH produced GH responses substantially greater than the sum of either agent alone, and inferred from that supra-additivity that the two act through independent mechanisms
Regarding safety, the GLP-1 receptor agonists group reported a higher frequency of all adverse events, significantly in dyspepsia, vomiting, and constipation, with non-significant differences in diarrhea, headache, and fatigue
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