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GLP-1 and GIP mostly work on appetite and food processing

The SURPASS-1 trial investigated the efficacy and safety of the three doses of 5, 10, or 15 mg tirzepatide in drug-nave patients with T2D who were not sufficiently controlled with a lifestyle intervention with diet and exercise versus placebo (70)

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[6] [7] These medicationsincluding semaglutide (Ozempic, Wegovy), dulaglutide (Trulicity), and liraglutide (Victoza, Saxenda)bind to GLP-1 receptors distributed throughout multiple organ systems, triggering a cascade of metabolic effects