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NF-B, a transcription factor with specific DNA-binding activity, is involved in classical pro-inflammatory signaling pathways [TNF-, IL-1, IKK (the IKK complex is a key regulator in the NF-B signaling pathway and consists of three subunits, IKK, IKK and NEMO)
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Front Pharmacol 13:821344 Luo Y, Alexander M, Gadina M, OShea JJ, Meylan F, Schwartz DM (2021) JAK-STAT signaling in human disease: from genetic syndromes to clinical inhibition
By integrating signaling, structural, and migration-focused research pathways into a single complex, it provides a powerful tool for exploring how tissues repair, regenerate, and adapt at the cellular level
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