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Bartels, S

Furthermore, the oligomerization domain mutant Mid51 (R169W) has recently been identified as a potential candidate genetic variant for PD as it can inhibit inter-lysosomal untethering events mediated by MLCSs, resulting in the dysregulation of lysosomal network dynamics (Wong et al., 2022)

Patients with Leber hereditary optic neuropathy should not take methyl B12, since this disease can get worse with high methyl B12 levels

However, relatively little research is currently available on milk thistle's overall safety for those who are pregnant or breastfeeding, so you should first consult with a medical professional to assess its place in your regimen