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Although meta-analysis (97 comparisons across 95 trials) demonstrated a statistically significant but clinically unimportant increase in FPG [fasting plasma glucose] (Hall et al., 2020), the impact of any diuretic on glucose homeostasis seems to depend on several factors, including the type of diuretic used and the specific metabolic context on which these diuretics are being studied (Grossman et al., 2011)

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These beneficial preclinical roles of GLP-1 in the cardiovascular system might translate to the clinical setting

Semaglutide slows but sustains