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Studies of healed tissue after combination treatment show better outcomes than either peptide alone: improved tensile strength (3040% stronger), better elasticity, less scar tissue (4050% less fibrosis), and superior functional recovery

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Glucocorticoids are released in a pulsatile manner and exert negative feedback through glucocorticoid receptors (GRs) and mineralocorticoid receptors (MRs) in the hypothalamus, pituitary, and hippocampus, thereby contributing to suppression of further CRH and ACTH secretion and maintenance of HPA-axis homeostasis (Gjerstad et al., 2018