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Rather than adding amino acids, DES involves removing the first three amino acids from the natural IGF-1 sequence

[20] Patients should be aware of red flags requiring medical attention, including severe persistent abdominal pain (possible pancreatitis), severe or persistent vomiting leading to dehydration, symptoms of gallbladder disease, vision changes, or allergic reactions

The short answer is that many people do take these medications together under the guidance of a healthcare professional

In some integrated care systems, GPs with enhanced diabetes training may initiate GLP-1 therapy directly, supported by local prescribing protocols