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Among the two distinct populations of Kupffer cells mentioned above, i.e., a major CD206 lo ESAM - population (KC1) and a minor CD206 high ESAM + population (KC2), only KC2-expressing genes are involved in liver metabolism regulation, including fatty acid metabolism both in steady-state and in diet-induced obesity in mice, as well as steatosis induction via the fatty acid transporter CD36 [52]