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PKA further activates the cAMP-response element binding protein (CREB) and the transducer of regulated CREB activity 2, leading to enhanced insulin receptor substrate 2 gene expression and promotion of -cell proliferation (26)

To conclude, in patients who qualify for GLP-1 RA drugs, there could be both potential benefits in overall pelvic functioning but also potential increase in dysfunction if there is present pelvic floor dysfunction previously