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The 2025 review also reported that in a large retrospective study of 461,328 adults initiating GLP-1 therapy, over 22% developed at least one nutritional deficiency within 12 months, with vitamin D the most common deficiency identified

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The GLP-1 Support Protein features 30 grams of whey protein, 5 grams of collagen for skin health, and the muscle-preserving ingredients myHMB and PeptiStrong to counteract muscle loss

Additionally, the cGMP second messenger is involved in mitochondrial biogenesis and UCP1 activation in brown adipose via the nitric oxide-sensitive soluble guanylyl cyclase pathway