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Figure 1 5-Methyltetrahydrofolate (5-methylTHF) is the main form of circulating folate in the plasma and can be transported into the cells by means of folate carriers and receptors, one the best characterized being the ubiquitously expressed reduced folate carrier (RFC), coded by the SLC19A1 gene (commonly known as RFC1 gene) (Hou and Matherly, 2014)

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