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The authors discuss how the synergistic mechanisms of the two drugs lead to superior weight loss and cardiometabolic improvements, positioning the combination as a significant advance in the treatment of obesity and type 2 diabetes

These cells also secrete potent pro-inflammatory cytokines, notably tumor necrosis factor-alpha (TNF-), interleukin-1 beta (IL-1), and interleukin-6 (IL-6), which recruit and activate neutrophils 8,9

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Microscopic examination found no changes in liver, spleen, lung, kidney, brain, thymus, or reproductive organs