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After verifying the results of the previous, highly controlled studies, the researchers expanded their study population to make it more reflective of HFpEF cases in clinical practice, finding that overall, the drugs were associated with a greater than 40% reduction in heart failure hospitalization or all-cause mortality as compared with sitagliptin
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Researchers have hypothesized that GLP-1 medications may reduce smoking through multiple mechanisms: decreased reward sensitivity, reduced appetite for nicotine, improved mood stability (via serotonin modulation), and reduced anxietyall factors that typically drive relapse