early life stress or chronic drug exposure [15,16,17], may lead to redox dysfunction and chronic oxidative stress, strongly linked to the pathophysiology of schizophrenia [18,19,20,21,22]
Glutathione helps calm this systemic inflammation, making it easier for the brain to enter restorative REM sleep
For example, in hereditary leiomyomatosis and renal cell cancer (HLRCC), a high level of fumarate caused by genetic mutation of fumarate hydratase induces the succination of Kelch-like ECH-associated protein 1 (KEAP1) accompanied by the consumption of a fumarate molecule 134,135
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