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Patients should seek same-day advice if weight gain is accompanied by breathlessness, ankle swelling, reduced urine output, or chest discomfort

"The implications of this trial are, we could wipe out the fat very early in the course of this disease, before it becomes a real threat to the liver and, potentially, reduce the long-term cardiac, metabolic, renal [kidney] and liver-related harm from obesity," said sub-study lead Dr