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Therefore, the debate about GLP-1 RAs in the perioperative period will probably continue until the next studies are available (Fig

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As such, the likely effectiveness of existing or potential interventions, including diet and lifestyle, for these conditions, from any tradition, depends on their effect on AMPK, directly or via calorie restriction. The authors say the hypothesis provides an over-arching physiological theory concerning the means of preventing and treating some of the chronic diseases that play a major role in population health.