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Additional experiments showed that increasing GSH levels using glutathione diethyl ester worsened diabetes, whereas blocking GSH synthesis with L-buthionine sulfoximine improved glucose tolerance, further highlighting the importance of GSH metabolism in disease progression

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58 It acts as a selective inhibitor of EGFR tyrosine kinase that significantly promotes VEGF expression when co-administered with radiation, thereby reducing the viability of osteosarcoma cells and increasing their sensitivity to radiotherapy