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The peptides cyclic structure is due to the formation of a lactam bridge, made through a linkage between the side-chain carboxyl group of the aspartic acid situated at the second position and the side-chain amino group of the lysine residue at the seventh position [4]
35 Fry D, Morales M
The preferred method of diagnosis is by using a punch biopsy, allowing the physician to sample multiple full thickness pieces of the tumor at multiple sites
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