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These neurons overlap with NE-expressing, but not CCK-expressing, NTS neurons [78], and their activation suppresses food intake without causing aversion [78]

There are some limitations acknowledged to this study, including a relatively low sample size (owing to the rarity of IIH) and a short follow-up period, partially mitigated by the standardized data collection and thorough quality control applied within the VIIH

Nausea, vomiting, and constipation are most common during initial weeks and dose increases, typically improving within days to weeks as the body adapts

In particular, combining 2-OHNA with other NAD + biosynthesis inhibitors like FK866 effectively kills NAPRT-proficient cancer cells resistant to single-agent treatments 217