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Another study also indicated that exendin-4 improved memory impairment by dampening the AMPK/NF-B pathway, reducing levels of IL-1 and TNF-, and increasing synaptic protein levels (118)
After one week of treatment, the mean body weight in the 2.4mg treated group decreased by 4.2% compared to the placebo group
B.DalgrdC.MllerS.SteenstrupT.KimuraM.ChristensenK
SAR425899 (Sanofi) is another example of a GLP-1/glucagon co-agonist which has been tested in Phase 1 trials
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