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The SELECT cardiovascular outcomes trial (N=17,604), published in NEJM 2023 (DOI: 10.1056/NEJMoa2307563), demonstrated a 20% reduction in major adverse cardiovascular events (MACE) -- the composite of cardiovascular death, non-fatal myocardial infarction, and non-fatal stroke -- in overweight or obese adults without diabetes
The first 12 weeks after birth are tender, tiring and expensive
Studies show these compounds may modestly improve liver fat clearance and energy metabolism, particularly in patients with hepatic steatosis or impaired choline metabolism
Other conditions common in people with obesity or diabetes can also contribute to fatigue, including sleep apnoea, thyroid disorders, and depression
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