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doi:10.1016/j.numecd.2019.12.005 29
Natural GLP-1 cannot be used therapeutically because it is rapidly degraded by the enzyme DPP-4 within 1-2 minutes, requiring continuous intravenous infusion for sustained effect
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A study using Swedish and Danish national databases compared cancer incidence in over 20,000 GLP-1 users versus other diabetes medications and found no elevated risk for colon or rectal cancers during follow-up periods extending beyond three years
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