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doi:10.1016/S0140-6736(23)01053-X

M2-like TAMs, which dominate many solid tumors, create a ferroptosis-resistant niche by exporting iron through ferroportin, supplying cysteine precursors that support glutathione synthesis, and releasing IL-10, TGF-, and lipid mediators that dampen oxidative stress

In the screen, we compared the effect that electrophiles (at 10 M) had on the viability of senescence and normal cells, identifying 72 candidates with senolytic activity (Fig

We pair it with a protein-priority framework (~100g a day) and a simple resistance routine because the muscle you keep is what makes the weight stay off