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J Biol Chem 263: 17106, 1988 23 Matzuk MM, Keene JL, Boime I: Site-specificity of the chorionic gonadotropin N-linked oligosaccharides in signal transduction
The bottom line CJC-1295 and ipamorelin are unlicensed growth-hormone-releasing peptides with limited human evidence and real safety concerns, especially when bought from unregulated sources
Alternative TB-500 protocols for different goals Daily low-dose protocol For patients who prefer more frequent, lower-volume injections: Dose: 750 mcg 1 mg daily , subcutaneous Duration: 12 weeks continuous, then 4 weeks off Provides steady-state tissue levels without peaks and troughs of twice-weekly dosing Preferred by some patients with needle anxiety (smaller volume per injection) Body-weight-based TB-500 dosing Some practitioners calculate by weight for greater precision: Loading: 3060 mcg/kg per injection , twice weekly Maintenance: 30 mcg/kg once weekly For a 75 kg patient: loading = 2.254.5 mg per injection
Of note is that GSTP1 also attenuated caspase 3 activity induced by the positive control tamoxifen by 50% (Supplementary Figure S4)
