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Propensity matching was used to assess whether prescribed semaglutide was associated with NAION in patients with type 2 diabetes (T2D) or overweight/obesity, in each case accounting for covarying factors (sex, age, systemic hypertension, T2D, obstructive sleep apnoea, obesity, hyperlipidemia, and coronary artery disease) and contraindications for use of semaglutide

Research suggests it can be used to explore epithelial barrier integrity, extracellular matrix remodeling, and cell migration in preclinical in-vitro and animal experiments

The FDA label sets the boundary at "more than 2 days" between consecutive doses

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