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Based on evidence from twin, family, and epidemiological studies, environmental factors and their interplay with hereditary factors have a significant impact on MDD ( Figure 1 illustrates the efficacy of probiotics, particularly butyrate-producing bacteria, to alleviate the physiological causes of MDD while also structurally modulating the intestinal flora

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They also offer protective effects against metabolic disorders through their ability to regulate inflammatory signaling pathways (289)